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Our laboratory demonstrated that SERT and αvβthree receptors colocalize in midbrain presynaptic terminals (Mazalouskas et al., 2015), suggesting that SERT is localized to multiprotein complexes coordinated by integrin αvβthree in midbrain synapses. Past experiments propose that in platelets, the Affiliation of SERT with activated αIIbβthree integrins, and its localization to adhesion complexes, are correlated with greater uptake activity (Carneiro et al.

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), suggesting that constitutive activation of integrin β3 decreases the Affiliation of SERT with integrin adhesion complexes.

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